PMSMatTrain: Novel Biomaterial-based Device for the Treatment of Progressive MS. An Integrated Pan-European Approach
Overview of the Programme
PMSMatTrain focuses on gaining a comprehensive understanding of the progressive phase of multiple sclerosis (PMS) from basics to translation, fully supported by eight beneficiaries (six research institutions and two SMEs).
The consortium will develop a multi-modal “tuneable” hydrogel-based medical device designed to bring about biphasic release of anti-inflammatory molecules and neuroprotective drugs as well as generating a clinically-relevant in silico model of drug elution and dispersal within the central nervous system. Using “state-of-the-art” 3D organotypic cultures and disease-relevant oligodendrocytes produced from MS patient-derived stem cells, the project will allow investigation MS pathophysiology as well as analysing the role of therapeutic molecules in combatting inflammation and promoting regeneration and neuroprotection. The industry partners will develop the end-device by providing standardised manufacturing protocols for scaled-up production and commercialisation of the final product.
PMSMatTrain is a multidisciplinary European Training Network that will educate and train 15 Early Stage Researchers in functionalised biomaterials, materials science, stem cell biology, in vitro & pre-clinical models, molecular biology, in silico modelling, functionalisation strategies and prototype design.
Programme fellows will experience both public and private sector research and development and will be best placed to secure employment as high calibre, innovative and well-trained graduates.
We started hiring (please see links below)
Syddansk Universitet, Denmark ESR 7
Universite Grenoble Alpes, France ESR 11
Westfaelische Wilhelms-Universitaet, Germany ESRs 6 & 8
Contipro AS, Czech Republic ESR 13
Neos Surgery SL., Spain ESRs 14 & 15
Universita Degli Studi Gabriele D'Annun, Italy ESR 12
This project has been funded by the European Union Horizon 2020 Programme (H2020-MSCA-ITN-2018) under the Marie Skłodowska-Curie Initial Training Network and Grant Agreement No. 813263.