As a proof-of-concept, we will develop a molecular logic sensor platform to diagnose endothelial dysfunction (ED). ED is believed to be the common onset point for a number of frequent diseases, including atherosclerosis – a chronic medical condition that can remain undetected for decades. During progression of atherosclerosis, so called plaques deposit at the walls of blood vessels leading to stenosis and eventually to serious clinical events such as heart attack or stroke. There is clearly a medical need for an early-stage diagnosis of atherosclerosis so therapeutic intervention can address disease progression long before a high and thus dangerous degree of stenosis is reached. By detection of key biomarkers for ED, such as low wall shear stress and low nitric oxide (NO) concentration, we aim to develop an analytical platform to diagnose ED and the diseases it possibly provokes at a primary level.
Leibniz-Institut Fuer Photonische Technologien E.V. (Coordinator), DCU, Friedrich-Schiller-Universitat Jena, Politechnika Gdanska, Uniwersytet Jagiellonski, Experimental Medicine Centre of the Slovak Academy of Sciences, Universiteit Leiden, Mimetas BV, Sciclus GMBH & CO. KG, Cosmologic GMBH & COKG, Mattek in Vitro Life Science Laboratories SRO, Dyomics GMBH, Microfluidic Chipshop GMBH, Interscience BV, Alexander Schiller.
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