The INSPIRED project will use omics technologies to address current knowledge gaps and map out the signalling networks controlled by IRE1 in order to find companion diagnostics for existing and novel drug compounds (WP4).

The project will test new and existing IRE1 modulatory drugs in both in vitro and in vivo models of cancer and neurodegenerative diseases (WP3) and will establish an inter-sectoral, interdisciplinary network of experts to share knowledge, expertise and unique reagents essential to delineate IRE1 signalling, with the specific aim of developing new small molecule drug compounds that can specifically modulate IRE1’s biological activities (WP2)


NUI Galway (Cooordinator), Institut National De La Sante Et De La Recherche Medicale, Enios Applications Idiotiki Kefalaiouchiki Etaireia, Metasysx GMBH, Mannkind Corporation, Universidad De Chile