Innovative model systems to study bone disease

The conventional drug treatments that target bone loss prevent osteoporotic fractures only in 50 % of sufferers, and the worldwide economic burden of treatment is expected to reach $ 132 billion by 2050. The current problem facing the international clinical research field is that our best understanding of bone biology and pathophysiology has been derived using 2D cell culture, which fails to capture vital biomechanical aspects of bones, or by studies in animals whose biology differs from that of humans. The EU-funded MEMETic project aims to develop advanced ex vivo models in a multicellular 3D environment to replicate the mechanobiological function of bone. The MEMETic models will improve our understanding of osteoporosis development and provide an evaluation of new therapies.

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