Advancing cell culture conditions for regenerative medicine, drug discovery and food security

Cells naturally reside in a very crowded/dense tissue context and are subjected simultaneously to numerous tissue-specific stimuli. However, traditional cell cultures are not only conducted in very diluted media, they are also mono-factorial in nature. As a result, biochemical reactions and biological processes occur very slowly, if at all, resulting in cells losing their phenotype and function. The EU-funded ACHIEVE project will first investigate the fundamentals of macromolecular crowding in eukaryotic cell culture to recapitulate in vitro the native tissue density. Subsequently, a multi-factorial approach, combining macromolecular crowding with other bio-inspired in vitro micro-environment modulators, will be employed for the development of functional cell-based regenerative medicine, drug discovery and food security products.

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