August 2018 STUDY DISCOVERS FIRST IN WORLD TREATMENT STRATEGY TO ADDRESS BREAST CANCER RELAPSE
CÚRAM Investigator Prof Afshin Samali, with a team of scientists from the Apoptosis Research Centre at NUI Galway have found that targeting the IRE1 stress response pathway may improve the response to chemotherapy and reduce relapse for patients with triple negative breast cancer. These first in world research findings were published today (15 August 2018) in the internationally renowned Nature Communications journal.
Triple negative breast cancer (TNBC) is one of the most aggressive and difficult to treat forms of breast cancer. This type of breast cancer accounts for around 15% of all breast cancers diagnosed and occurs more frequently in younger women. Unlike other forms of breast cancer, there are no targeted therapies available for triple negative breast cancer. Currently, chemotherapy is the mainstay treatment, and although initially successful, a large percentage of TNBC patients relapse within one to three years of treatment and have a poor long-term prognosis.
The exact mechanism of the tumour relapse post chemotherapy remained unknown until now. In this study, the research team, led by CÚRAM Investigator Professor Afshin Samali at NUI Galway, have shown for the first time that IRE1, which is a cellular stress sensor that normally acts to alleviate short-term stresses within cells, such as lack of nutrients or oxygen, is a central driver of treatment-related relapse.
Professor Afshin Samali, Director of the Apoptosis Research Centre and CÚRAM Investigator at NUI Galway, said: “This study is the result of extensive laboratory experiments, analysis of breast cancer patient samples, testing pre-clinical models of triple negative breast cancer and collaboration with our international and industry partners. The new era of precision oncology aims to tailor treatments to individual cancer patients and here at NUI Galway, we are excited to identify a new therapeutic strategy for triple negative breast cancer patients who are most in need of better treatment options. Furthermore, this strategy may benefit many other cancer patients whose cancer cells rely on activated cell stress responses to survive.”
Dr Susan Logue, SFI Starting Investigator and first author of the study at NUI Galway, said: “This work has uncovered a previously unknown role for IRE1 and suggests that it may represent a good therapeutic target for the treatment of triple negative breast cancer. While further research is needed, this work is a great example of how curiosity-driven basic research can lead to translational outcomes with real potential to impact on patient treatment.”
The team discovered that chemotherapy can activate the IRE1 stress response in triple negative breast cancer, leading to the production of survival signals that are pumped out of the cell to support the growth of new cancer cells. Most importantly, the study showed that this process can be halted by specifically inhibiting IRE1 using a clinically-relevant, small molecule drug called MCK8866 that not only improves the effectiveness of the initial chemotherapy treatment, but also reduces relapse of this aggressive form of breast cancer.
Using triple negative breast cancer cells treated with chemotherapy, the research team found that blocking IRE1 activity reduced the production of survival signals, and in turn reduced the growth of new cancer cells by 50%. Furthermore, in a pre-clinical model of TNBC, the drug increased the effectiveness of chemotherapy treatment, leading to regression of 8 out of 10 cancers compared to regression of just 3 out of 10 cancers using chemotherapy alone. The combination of the MCK8866 drug with chemotherapy also reduced tumour relapse in this pre-clinical model of triple negative breast cancer.
In addition to these laboratory-based experiments, an analysis of 595 patient tumours revealed that triple negative breast cancer tumours displayed the highest IRE1 activity compared to other subtypes, suggesting that IRE1 may be of particular importance in TNBC. This discovery suggests that combining chemotherapy with IRE1 inhibitors could offer substantial benefits for triple negative breast cancer patients.
The study was funded by Science Foundation Ireland, Irish Cancer Society and Horizon 2020 with initial funding from Breast Cancer Now.
To read the full study in Nature Communications, visit: http://www.nature.com/ncomms
For Press contact Gwen O’Sullivan, Press and Information Executive, NUI Galway at firstname.lastname@example.org or 091 495695.
Notes to Editors
Apoptosis Research Centre, NUI Galway
The Apoptosis Research Centre is located in the Biomedical Sciences Building at NUI Galway, is an interactive network of researchers investigating cell stress responses and cell death and their relationship to cancer. It is the only Cell Death Research Centre in Ireland. Led by Professor Afshin Samali, the goal of the Centre is to understand how cancer cells have adapted to promote their own survival, and using this knowledge, to uncover new ways to combat cancer progression. For more information, visit: http://www.apoptosis.ie
CÚRAM, the SFI Centre for Research in Medical Devices is part of the Science Foundation Ireland Research Centre network. It aims to radically improve the quality of life for patients living with chronic illnesses, by developing the next generation of smart, implantable medical devices. CÚRAM’s academic partners include the National University of Ireland Galway, Royal College of Surgeons Ireland, Trinity College Dublin, University College Dublin, University College Cork, University Limerick and Clinical Research Development Ireland. Clinical targets include cardiovascular illnesses, diabetes, neurodegenerative diseases such as Parkinson’s disease, musculoskeletal and respiratory illnesses as well as soft tissue and wound healing. CÚRAM brings together clinical, industry and research teams with expertise in biomaterials, tissue engineering and regenerative medicine, glycoscience and device design. Read more at www.curamdevices.ie or follow on Twitter @curamdevices.